Cognitive function restoration in rats with chronic brain ischemia using Semax and hopantenic acid comprehensive administration

The relevance and importance of treating patients with ischemic brain lesions are indisputable. Chronic processes in the occur much more frequently than acute cerebral circulation disorders, leading to prolonged disability being main contributors a significant number strokes. Cognitive dysfunctions prevail dynamics post-ischemic period often primary determinants severity residual organic subsequent functional impairments brain. aim study is investigate effectiveness separate combined administration Semax hopantenic acid pharmacological correction cognitive disorders rats experimental chronic ischemia. It has been established that ischemia exhibit from 1st day, manifested worsened learning processes, short-term long-term memory functioning context conditioned active avoidance feeding reflexes. shown application contributes restoration process improvement mnestic functions most pronounced nootropic effect was registered under conditions acid, starting 3rd day study. Subsequently, terms anti-ischemic efficacy, follows, which realized least neuroprotective belongs 7th author considers obtained data as groundwork for feasibility clinically testing effects cases comprehensive pathogenetically justified aimed at activating sanogenetic mechanisms.